This lecture was help at First Nations University of Canada in August 2012 in conjunction with the meeting of the Canadian Prairie Theoretical Physics Network (CPTPN) in Regina. In this lecture, Leroy Little Bear discusses notions of flux, the connection between energy waves and the spirit, the understanding that everything in creation is animate and that all things in creation are related. He also talks about the importance of renewal, space referencing and the fact that Indian languages are "process oriented." He explores the notion of chaos in Native science and quantum physics, as well as comparing understandings of time, cause and effect, reality and knowledge. Finally he considers current scientific discoveries like the Higgs particle and superstring theory.